Living Organisms
Cayman Chemical BIX01294hydrochLRIde hydra 5mg
A selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 μM); less effectively inhibits G9a-like protein (GLP; IC50 = 38 μM) and has no effect on other known histone methyltransferases
Cayman Chemical FrovatrIptnsuccInAT hydra 50mg
An agonist of 5-HT1B and 5-HT1D receptors (Kis = 2.51 and 3.98 nM, respectively); selective for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1E, 5-HT1F, 5-HT2A, 5-HT2C, 5-HT3, and 5-HT7 receptors, as well as dopamine D1, D2, and D3, histamine H1, and α1-adrenergic receptors (Kis = >50 nM); induces contractions in human basilar arteries isolated post-mortem, coronary arteries from transplant recipient hearts, and coronary arteries from donor hearts unsuitable for transplantation (EC50s = 13.8, 41.69, and 15.49 nM, respectively); increases carotid vascular resistance in closed-chest and open-chest anesthetized dogs (ED50s = 6 and 1 nmol/kg, i.v., respectively)
Cayman Chemical CefotIamhydrochlorIde hydra 1g
A broad-spectrum cephalosporin antibiotic; inhibits the growth of S. aureus (MIC50 = 0.26 UG/ml), as well as P. aeruginosa, E. coli, and H. influenzae (MIC50s = 1, 0.06, and 0.01 UG/ml, respectively); increases survival in mouse models of infection with strains of S. aureus (ED50s = 3.5 and 8.3 mg/kg) and E. coli (ED50s = 0.5-25 mg/kg)
Cayman Chemical CefsulodInsodIum salt hydra 1g
A cephalosporin antibiotic; active against 45 isolates of P. aeruginosa (MIC90 = 3.1 UG/ml) and acts synergistically against P. aeruginosa isolates when combined with gentamicin, tobramycin, amikacin, or mezlocillin; binds to P. aeruginosa PBP1a, PBP1b, and PBP3 but not PBP2, PBP4, or PBP5; increases survival in mice infected with various P. aeruginosa strains (ED50s = 1.93-137 mg/kg for all)
Cayman Chemical Clodronate sodium salt hydra
A non-nitrogenous bisphosphonate that inhibits hydroxyapatite crystal growth (IC50 = 1.34 µM) and bone resorption; is cytotoxic to both osteoclasts and macrophages and has been used in biological research to selectively induce apoptosis of macrophage-like cells and cancer cells
Sigma Aldrich Fine Chemicals Biosciences Hirudin from leeches lyoph
Hirudin is a 7 kDa acidic protein containing 65 amino acid residues that has an isoelectric point of 3.5-4.0. It is not glycosylated and lacks tryptophan arginine and methionine residues. It is chemically stable between pH 2-12 and at temperatures up to 80C.
